Additional file 10: of Isocitrate dehydrogenase 1âsnail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability
Figure S6. Gene set enrichment analysis for differential expression of genes in MDA-MB-231 cells transfected with si-IDH1 compared with those transfected with scramble control. (a) Differential expression of genes (upregulated or downregulated twofold change) was identified using a microarray approach. These gene sets were significantly enriched in metastasis-associated terms from the Kyoto Encyclopedia of Genes and Genomes. (b) Schematic putative signaling pathway illustrating IDH1-modulated cancer cell invasion. (TIFF 1728 kb
