The chemical heterogeneity of fetal hemoglobin (Hb F) due to variable
ratios of the Gγ and Aγ globin subunits reflects genetic complexity
because of common dimorphisms such as Hb F Sardegna (or Aγ75(E19)
Ile>Thr; also known as AγT) in Caucasians, and common variants such the
Gγ globin variant, Hb F Malta I (or Gγ117(G19) His>Arg) that is in tight
linkage disequilibrium with the β globin variant Hb Valletta (or β87(F3)
Thr>Pro) and is found in 1.8% of neonates from Malta.peer-reviewe
