The aims of this research were to determine: 1) the differences of learning outcomes between students who were taught using POE (predict-observe-explain) model and conventional learning colloidal subject, 2) the effect of POE (predict-observe-explain) model toward student learning outcomes colloidal subject. The from of research was a quasi-experimental with nonequivalent control group design. Classes of XI MIA 3 as experiment and MIA 1 as control were selected by cluster random sampling technique. Achievement test and interview was used to collect data. According to data analysis, average score of experiment and control classes were 74.36 and 67.36 respectively. According to U-Mann Withney test, the value of student of Asymp.Sig (2-tailed) was 0.023 which meant that there was a difference in learning outcome between the control class and experimental class colloidal subject. The result of effect size was 0.39 which meant POE (predict-observe-explain) model had of 18.79% influenced toward student learning outcomes improvement
