The red palm weevil (RPW) is the major pest of palms in the Mediterranean region. One of the most interesting control solutions for this pest is endotherapy, comprising injections of biologically active substances directly into the stem of the palm. The objective of the present work was to study the ovicidal and adulticidal properties of two neonicotinoid insecticides (clothianidin and thiamethoxam) under laboratory conditions, to obtain evidence for application of endotherapy in the control of RPW infestations. Our results show that both commercial compounds display a dose-dependent action and exhibit different modes of action: clothianidin is more rapid in its action, but in general is less effective for control of the adult stages, while thiamethoxam is more effective, but its action requires longer to show efficacy. The eggs are much less sensitive to treatments, especially for clothianidin
