Patients reported a negative impact on the QoL of delayed emesis after chemotherapy. Poor prophylaxis of patients' nausea and vomiting after chemotherapy interferes with patients' QoL. Medical and behavioral interventions may help to alleviate the negative consequences of chemotherapeutic treatment in patients with gynecologic cancers treated with suboptimal antiemetics

Atthobari, Jarir

Dwiprahasto, Iwan

Gelderblom, Hans

Guchelaar, Henk-Jan

Hakimi, Mohammad

Kaptein, Ad A

Mustofa, Mustofa

Nortier, Johan W R

Perwitasari, Dyah Aryani

Putter, Hein

English

Perwitasari, D.A.

Atthobari, J.

Mustofa, M.

Dwiprahasto, I.

Hakimi, M.

Gelderblom, H.

Putter, H.

Nortier, J.W.R.

Guchelaar, H.J.

Kaptein, A.A.

Leiden University Scholary Publications

Impact of Delayed Chemotherapy Induced Nausea and Vomiting on Quality of Life in Indonesian Patients with Gynecological Cancer

Development and application of statistical models for medical scientific researc

Impact of Chemotherapy-Induced Nausea and Vomiting on Quality of Life in Indonesian Patients With Gynecologic Cancer

Universitas Ahmad Dahlan Repository

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Impact of chemotherapy-induced nausea and vomiting on quality of life in indonesian patients with gynecologic cancer.

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BackgroundQuality of life (QoL) has become a major outcome in the treatment of patients with cancer. This study is aimed at examining the impact of chemotherapy-induced nausea and vomiting on QoL of patients with gynecologic cancer in Indonesia.MethodsChemotherapy-naive patients with gynecologic cancer, who were treated with cisplatin at a dosage 50 mg/m2or higher as monotherapy or as part of combination chemotherapy regimens, were recruited in the Oncology Department, Dr. Sardjito Hospital, Yogyakarta, Indonesia. Quality of life was assessed by using the Indonesian version of the European Organization for Research and Treatment for Cancer of Quality of Life Questionnaire and Short Form-36, administered immediately before and on day 5 after chemotherapy administration. Patients used a daily diary to record nausea and vomiting during 5 days after chemotherapy.ResultsMost (74.9%) of the 179 patients experienced delayed emesis during the 5 days after chemotherapy despite prophylactic use of antiemetics. The delayed nausea and emesis caused significant negative impact on patients’ QoL. Nausea in the delayed phase caused negative effects on patients’ QoL.ConclusionsPatients reported a negative impact on the QoL of delayed emesis after chemotherapy. Poor prophylaxis of patients’ nausea and vomiting after chemotherapy interferes with patients’ QoL. Medical and behavioral interventions may help to alleviate the negative consequences of chemotherapeutic treatment in patients with gynecologic cancers treated with suboptimal antiemetics.</jats:sec

Impact of chemotherapy-induced nausea and vomiting on quality of life in indonesian patients with gynecologic cancer.

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Leiden University Scholary Publications

Leiden University Scholary Publications

Universitas Ahmad Dahlan Repository

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