Broeng, Jes

Nguyen, Ngoc Mai

Petersen, Paul Michael

We have developed a new therapeutic LED lamp that modulates with 40 Hz the neuron responses in different parts of the brain without affecting the human vision. The lamp may in the future be used to treat patients with Alzheimer’s disease

Online Research Database In Technology

                       General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.  • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal   If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.     Downloaded from orbit.dtu.dk on: Apr 10, 2018How to treat Alzheimer’s with new LED light technologyNguyen, Ngoc Mai ; Petersen, Paul Michael; Broeng, JesPublication date:2017Document VersionPublisher's PDF, also known as Version of recordLink back to DTU OrbitCitation (APA):Nguyen, N. M., Petersen, P. M., & Broeng, J. (2017). How to treat Alzheimer’s with new LED light technology.Abstract from 5th internation workshop on LED and Solar Applications, Kgs. Lyngby, Denmark.O.15  5th International workshop on LEDs and solar applications How to treat Alzheimer’s with new LED light technology  Ngoc Mai Nguyen1,*, Paul Michael Petersen2 and Jes Broeng2 1University of California, Berkeley and Berkeley, CA, USA 2Technical University of Denmark and Lyngby, Denmark *E-mail:  mnguyen61288@berkeley.edu  Abstract— We have developed a new therapeutic LED lamp that modulates with 40 Hz the neuron responses in different parts of the brain without affecting the human vision. The lamp may in the future be used to treat patients with Alzheimer’s disease Keywords— LED; Alzheimer’s; optogenetic; light therapy (3-5 words) I. INTRODUCTION Light-emitting diodes (LEDs) have been long utilized as a light source for industrial and commercial environments. In the past 10 years,  it has become the dominant technology used for backlight displays such as ipads, laptops, and television sets. Its potential to be utilized for medical application have recently been examined for circadian disruption and neuropathological diseases such as Alzheimer’s. In this lettter, we will discuss how new LED technologoy can be utilized to treat or prevent the progression of neurodegenerative diseases.     II. FIGURES AND TABLES Fig. 1. First mock up of how the light protoype.       III. SUMMARY One of the biggest demographic challenges in Europe and the US is the rapidly growing number of people with Alzheimer’s and dementia (~30% of the world population has or will develop the neurodegenerative disease). Dementia is one of the leading causes of death among those 60 years and over.  The increase in the number of Europeans and Americans living with dementia is already creating immense challenges for the health and social systems costing upwards of 259 billion dollars in healthcare. For most people, the cognitive decline starts with a failing memory and a lack of perception and attention.  One of the things that have been attributed to the progression of Alzheimer’s is the altered oscillatory rhythmic activity that could lead to cognitive abnormalities and beta amyloid developmet in the brain [1].  This desychronization of neuronal oscillations can be detected prior to the development of symptoms of Alzheimer’s.  Recently the use of ligth therapy as a non-invasive tool has been explored in the treatment of Alzheimer’s. Studies have shown that flickering light at 40 hertz can reduce the beta amyloid plaque production (early clinical signs of Alzheimer’s) in mice by stimulating the brain wave activity in the visual cortex [2]. However, trials on mice cannot be duplicated in humans due to the negative side effects of flickering that can induce very same positive effects. The current study addresses the side effects induced by flickering lights by utilizing the brains ability to detect and respond to specific wavelength that differ from the wavelength sensitivity of the eye vision [3], that are no longer perceived as a flicker by the visual cortex but the increase in gamma oscillations still be detected.  ACKNOWLEDGMENT Lance Kriegsfeld (UC Berkeley, Department of Psychology) Marcus Schultz Carstensen (DTU, Department of Physics) REFERENCES   1. Palop, J.J. and L. Mucke, Network abnormalities and interneuron dysfunction in Alzheimer disease. Nature Reviews Neuroscience, 2016. 17(12): p. 777-792. 2. Iaccarino, H.F., et al., Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature, 2016. 540(7632): p. 230-+. 3. La Morgia, C., et al., Melanopsin-expressing retinal ganglion cells: implications for human diseases. Vision Research, 2011. 51(2): p. 296-302.  15

How to treat Alzheimer’s with new LED light technology

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How to treat Alzheimer’s with new LED light technology

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