Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Aschard, H. (Hugues); Bandinelli, S. (Stefania); Beekman, M. (Marian); Berndt, S.I. (Sonja); Bidlingmaier, M. (Martin); Broer, L. (Linda); Cappola, A.R. (Anne); Ceda, G.P. (Gian Paolo); Chanock, S.J. (Stephen); Chen, M.-H. (Ming-Huei); Chen, T.C. (Tai C.); Chen, Y.D. (Y.); Chung, J. (Jonathan); Del Greco Miglianico, F. (Fabiola); Duijn, C.M. (Cornelia) van; Eriksson, J. (Joel); Ferrucci, L. (Luigi); Friedrich, N. (Nele); Gnewuch, C. (Carsten); Goodarzi, M. (Mark); Grarup, N. (Niels); Guo, T. (Tingwei); Hammer, E. (Elke); Hayes, R.B. (Richard); Heemst, D. (Diana) van; Hicks, A.A. (Andrew); Hofman, A. (Albert); Houwing-Duistermaat, J.J. (Jeanine); Hu, F. (Frank); Hunter, D. (David); Husemoen, L.L.N. (Lise Lotte); Isaacs, A.J. (Aaron); Jacobs, K.B. (Kevin); Janssen, J.A.M.J.L. (Joop); Jansson, J.-O. (John-Olov); Jehmlich, N. (Nico); Johnson, S. (Simon); Juul, A. (Anders); Kaplan, R.C. (Robert); Karlsson, M. (Magnus); Kilpeläinen, T.O. (Tuomas); Kovacs, P. (Peter); Kraft, P. (Peter); Li, C. (Chao); Linneberg, A. (Allan); Liu, Y. (YongMei); Loos, R.J.F. (Ruth); Lorentzon, M. (Mattias); Lu, Y. (Yingchang); Maggio, M. (Marcello); Meigs, J.B. (James); Mellström, D. (Dan); Mägi, R. (Reedik); Nauck, M. (Matthias); Nethander, M. (Maria); Newman, A.B. (Anne B.); Ohlsson, C. (Claes); Pollak, M.N. (Michael); Pramstaller, P.P. (Peter Paul); Prokopenko, I. (Inga); Psaty, B.M. (Bruce); Qi, Q.; Reincke, M. (Martin); Rimm, E.B. (Eric B.); Rotter, J.I. (Jerome I.); Saint Pierre, A. (Aude); Schurmann, C. (Claudia); Seshadri, S. (Sudha); Sjögren, K. (Klara); Slagboom, P.E. (Eline); Strickler, H.D. (Howard D.); Stumvoll, M. (Michael); Suh, Y. (Yousin); Sun, Q. (Qi); Svensson, J. (Johan); Tanaka, T. (Toshiko); Tare, A. (Archana); Teumer, A. (Alexander); Tönjes, A. (Anke); Uh, H.-W. (Hae-Won); Vandenput, L. (Liesbeth); Vasan, R.S. (Ramachandran Srini); Völker, U. (Uwe); Wallaschofski, H. (Henri); Willems, S.M. (Sara); Zhang, C. (Cuilin)

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Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Authors: H. (Hugues) Aschard
S. (Stefania) Bandinelli
M. (Marian) Beekman
S.I. (Sonja) Berndt
M. (Martin) Bidlingmaier
L. (Linda) Broer
A.R. (Anne) Cappola
G.P. (Gian Paolo) Ceda
S.J. (Stephen) Chanock
M.-H. (Ming-Huei) Chen
T.C. (Tai C.) Chen
Y.D. (Y.) Chen
J. (Jonathan) Chung
F. (Fabiola) Del Greco Miglianico
C.M. (Cornelia) van Duijn
J. (Joel) Eriksson
L. (Luigi) Ferrucci
N. (Nele) Friedrich
C. (Carsten) Gnewuch
M. (Mark) Goodarzi
N. (Niels) Grarup
T. (Tingwei) Guo
E. (Elke) Hammer
R.B. (Richard) Hayes
D. (Diana) van Heemst
A.A. (Andrew) Hicks
A. (Albert) Hofman
J.J. (Jeanine) Houwing-Duistermaat
F. (Frank) Hu
D. (David) Hunter
L.L.N. (Lise Lotte) Husemoen
A.J. (Aaron) Isaacs
K.B. (Kevin) Jacobs
J.A.M.J.L. (Joop) Janssen
J.-O. (John-Olov) Jansson
N. (Nico) Jehmlich
S. (Simon) Johnson
A. (Anders) Juul
R.C. (Robert) Kaplan
M. (Magnus) Karlsson
T.O. (Tuomas) Kilpeläinen
P. (Peter) Kovacs
P. (Peter) Kraft
C. (Chao) Li
A. (Allan) Linneberg
Y. (YongMei) Liu
R.J.F. (Ruth) Loos
M. (Mattias) Lorentzon
Y. (Yingchang) Lu
M. (Marcello) Maggio
J.B. (James) Meigs
D. (Dan) Mellström
R. (Reedik) Mägi
M. (Matthias) Nauck
M. (Maria) Nethander
A.B. (Anne B.) Newman
C. (Claes) Ohlsson
M.N. (Michael) Pollak
P.P. (Peter Paul) Pramstaller
I. (Inga) Prokopenko
B.M. (Bruce) Psaty
Q. Qi
M. (Martin) Reincke
E.B. (Eric B.) Rimm
J.I. (Jerome I.) Rotter
A. (Aude) Saint Pierre
C. (Claudia) Schurmann
S. (Sudha) Seshadri
K. (Klara) Sjögren
P.E. (Eline) Slagboom
H.D. (Howard D.) Strickler
M. (Michael) Stumvoll
Y. (Yousin) Suh
Q. (Qi) Sun
J. (Johan) Svensson
T. (Toshiko) Tanaka
A. (Archana) Tare
A. (Alexander) Teumer
A. (Anke) Tönjes
H.-W. (Hae-Won) Uh
L. (Liesbeth) Vandenput
R.S. (Ramachandran Srini) Vasan
U. (Uwe) Völker
H. (Henri) Wallaschofski
S.M. (Sara) Willems
C. (Cuilin) Zhang
Publication date: 1 October 2016
Publisher: 'Wiley'
Doi

Abstract

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Throug

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