Effect of natural products on hematopoiesis

Abstract

Prirodne sastavnice (sekundarni biljni metaboliti) su tvari sintetizirane u sekundarnim reakcijama iz primarnih metabolita. Danas se sve više istražuju njihova svojstva i sve smo više upoznati s njihovim učinkom na ljudsko zdravlje. U ovom radu izložen je kratak pregled procesa hematopoeze, krvnih stanica i prirodnih sastavnica te njihovog utjecaja na zdravlje i hematopoezu. Mnogi biljni pripravci kao i pojedine biljne sastavnice imaju antimikrobno, protuupalno te antitumorsko djelovanje te se njihova svojstva sve više istražuju u svrhu zaštite ljudskog zdravlja. Učinak prirodnih sastavnica na hematopoezu je uglavnom stimulativan, iako postoje i neke prirodne sastavnice koje inhibiraju razvoj određene hematopoetske linije. Također je pokazano da štite stanice koštane srži od zračenja te djeluju stimulativno na oporavak nakon kemoterapije.Natural products (plant secondary metabolites) are supstances derived from primary metabolites in secondary reactions. Now their chemical properties are being increasingly investigated and we become more and more aware of their impact on human health. This paper represent a brief review of hematopoiesis, blood cells and natural products and their effect on health and hematopoiesis. Many plant extracts and natural products have antimicrobal, anti-inflammatory and antitumor effect thus their properties are increasingly invesigated for the purpose of protecting human health. Effects of natural products on hematopoiesis is mainly stimulatory, although some natural products have inhibitory effect on development of specific hematopoietic lineage. It has been also proved that they have an protective and stimulative effect on bone marrow cells in case of radiation