Polycyclic aromatic hydrocarbons (PAHs) bound to PM2.5 are
genotoxic carcinogens that can also elicit non-cancer effects. Previous
studies report substantial burdens of PAHs-related lung cancer, but no
estimate for other cancer types or non-carcinogenic burden. Here, we
assessed the burden of disease, in DALYs/person/year, attributable to
thirteen priority PAHs in PM2.5 in Nagpur district, for several endpoints
linked to benzo[a]pyrene, to inform policy decision-making for
mitigation. We conducted detailed assessment of concentrations of PAHs in
nine areas, covering urban, peri-urban and rural environments, from
February 2013 to June 2014. PAHs concentrations were converted to
benzo[a]pyrene equivalent concentration for cancer and non-cancer effects
using relative potency factors and relative toxicity factors derived from
quantitative structure-activity relationships, respectively. We derived
severity for each endpoint using GBD 2016 dataset. The annual average
concentration of total PAHs in Nagpur district was 458±246 ng/m3, and
results in 0.011 DALYs/person/year (49,000 DALYs/year), much higher than
the WHO reference limit of 1×10-6 DALYs/person/year. PAHs-related burden
follow this order: developmental (mostly cardiovascular) impairment
(55.1%) > cancer (26.5%) or lung cancer (23.1%) > immunological
impairment (18.0%) > reproductive abnormally (0.4%). The estimated
DALYs/person/year is high. Mitigation intervention should target
combustion sources having the highest level of exposure
