Yusoff, Khatijah

Universiti Putra Malaysia Institutional Repository

Universiti Putra MalaysiaBioCarrier™-A Novel Molecular Carrier from Newcastle Disease VirusVarious kinds of carrier molecules have been used to deliver nucleic acids,drugs, vaccines and other important compounds. We have developed a mo-lecular carrier for immunogenic peptides, which can be used for the development of multi-component vaccines, diagnostic reagents and the delivery of novel therapeutics or drugs(Malavslan Patent Pending: PI 20004837 and PI 20021709; US Patent Application No.09/970,.851).We have discovered that the nucleocapsid protein of a local Malaysian poultry virus (Newcastle diseasevirus) produced in Escherichia coli assembles into ring-like and herringbone-like particles. It is possible tomanipulate the lengths of theseparticles by genetically engineeringone end of this nucleocapsid protein.In addition, these particles can befused with foreign polypeptides.Some of the advantages of this car-tier molecule are its ability to in-crease the solubility of proteins,deliver immunogenic peptides orproteins in animals, as well as aidthe purification of specific protein molecules.BioCarrier™: A novel molecular carrier from Newcastle Diseasevirus-Solutions to proteinSeveral fusion proteins have been constructed. These include the antigenic regions of the Newcastle dis-ease virus, Nlpah virus, hepatitis B virus, enterovirus virus 71, chicken anemia virus, and infectious bron-chitis virus. Chickens inoculated with these particles mounted an immune response against the foreignpeptides, supporting the use of these particles as carriers for immunogens in the development of multi-component vaccines and immunological reagents.For further information, kindly contact:Prof. Dr. Khatijah YusoffDepartment of MicrobiologyFaculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 UPM. Serdang. SelangorMalaysiaTel: +603 8946 6701, 012-2066305FalC +603 8943 0913Esrnail: khatijah@fsas.upm.edu.my22

BioCarrier™ - a novel molecular carrier from Newcastle disease virus

http://psasir.upm.edu.my/51876/1/A%20novel%20molecular%20carrier%20from%20Newcastle%20disease%20virus.pdf

BioCarrier™ - a novel molecular carrier from Newcastle disease virus

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Universiti Putra Malaysia Institutional Repository