MOESM3 of Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

Abstract

Additional file 3: Figure S2. Effects of paeoniflorin on histopathology of the entorhinal cortex area of rats after cerebral ischemia. Representative photomicrographs of hematoxylin-eosin-stained entorhinal cortex region of either sham-operated rats (a, g) or rats that had been subjected to four-vessel occlusion followed by the treatment with saline (4-VO; b, h), paeoniflorin (4-VO+PF; 40 mg/kg/d; c, i), paeoniflorin+AM630 (4-VO+PF+AM630; 40 + 3 mg/kg/d; d, j), AM630 (4-VO+AM630; 3 mg/kg/d; e, k) or HU308 (4-VO+HU308; 3 mg/kg/d; f, l) for consecutive 28 days. Boxed regions in a–f are shown in j–l, respectively. Scale bar: 50 µm