<p><b><i>Purpose:</i></b> We present the advantages and technique variations of 27-G vitrectomy in a variety of surgical retina cases. <b><i>Methods:</i></b> Patients with epiretinal membrane, retinal detachment, and proliferative diabetic retinopathy with vitreous hemorrhage and tractional detachments underwent 27-G vitrectomy. We present technique tricks, solutions to various problems and pitfalls, and the advantages of 27-G vitrectomy. <b><i>Results:</i></b> Postoperative visual acuity improved significantly in all patients. Anatomical restoration was achieved in all cases. <b><i>Conclusions:</i></b> 27-G vitrectomy offers satisfactory outcomes in a wide variety of surgical retina cases and shows significant advantages in the postoperative course.</p