<p>Genes were grouped based on relevant biological activities/pathways. Right Panel: Variants identified as potential drivers (red: high-confidence drivers; gold: lower confidence drivers. Inset: Color coding scheme for types of mutations (mis-sense, termination, splice site, in-frame deletion), confidence of driver likelihood (high-confidence, lower confidence). Asterisks indicate mutations present in the COSMIC (<u>C</u>atalogue <u>o</u>f <u>S</u>omatic <u>M</u>utations in <u>C</u>ancer) database. The same coding scheme is used in Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0194790#pone.0194790.g002" target="_blank">2</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0194790#pone.0194790.g005" target="_blank">5</a>.</p
