MOESM1 of pH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents

Abstract

Additional file 1. Additional figures, experimental details and parameters. Part S1: Preparation of Fe3O4@SiO2@PAA-cRGD; part S2, including the Fig. S1–S11: 1H NMR, 13C NMR, MS, UV spectra and structure for compounds; part S3: Cell culture; part S4: Specific parameters of MR contrast properties test; part S5, including Table S1 and Fig. S12–16: Hydrodynamic diameters of the nanoparticles tested by DLS; part S6: Drug loading and in vitro release; part S7, including Fig. S17: Biodistributions tested by ICP-MS