Additional file 6: of Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma
Figure S6. RU cells derived from SupM2 were transfected with either Sox2 siRNA or scrambled siRNA which served as a negative control. Cells after siRNA transfection were exposed to 0.3 mM H2O2 re-challenge. At day 4 of the H2O2 re-challenge experiment; cells were subjected to 200 ng/mL doxorubicin for additional 48 h, following by the trypan blue exclusion assay-based cell viability analysis. The Western blots in the right panel demonstrated the Sox2 knockdown efficiency in RU cells from SupM2 24 h post transfection. (PDF 48 kb
