Wind energy is gaining ever increasing popularity among renewable energy sources. In some European countries installed wind turbine capacity has reached over 20 % of the total power generation capacity. This paper examines aerodynamic performance sensitivity of wind turbine blades for main design variables. The sensitivity analysis has been conducted on a sample 100 kW three-bladed horizontal axis wind turbine (HAWT). Taguchi robust design techniques and orthogonal arrays have been used to perform experimental optimization using five main parameters: airfoil NACA profile, root chord length, tip chord length, root radius and chord profile distribution along the blade’s length. The airfoil profiles and their aerodynamic data are taken from the NACA airfoil database for which experimental lift and drag coefficient data are available. The airfoils for the studied blades have the same profile from root to tip. Three sets of analyses have been performed according to three different base load wind speeds. The sensitivity results have been presented for the optimal tip speed ratio values