Objective: The aim of this study was to investigate the incidence and mortality of colorectal cancer and its relationship with the Human Development Index (HDI) in 2018. Materials and Methods: The present study is a descriptive-analytic study that is based on the extraction of cancer incidence and mortality data from the GLOBOCAN 2018. Results: The results showed that there is a positive and significant correlation between incidence (R=0.722, p<0.0001) and mortality (R=0.62, p<0.0001) of colorectal cancer with HDI. There was found a positive and significant correlation between the incidence of cancer with GNI (r=0.564, p<0.0001), MYS (r=0.732, p<0.0001), LEB (r=0.706, p<0.0001) and EYS (r=0.754, p<0.0001). Conclusions: HDI can be important in reducing the incidence and mortality of colorectal cancer