Background Acinetobacter is a type of pathogenic bacteria are aerobic gram-negative basilus and naturally relatively sensitive to some antibiotics. Acinetobacter infection opportunistic disease-shaped. Multi-drug resistant Acinetobacter% u2018akan abbreviated as MDRAB. Multiple drug resistant Acinetobacter is not a new phenomenon, but it has always been resistant to some antibiotics.And it can cause death if infected in patients who have sepsis, especially in childrenPURPOSE What is the relationship MDRO Acinetobacter infection mortality in patients with sepsis in PICU dr Kariadi Semarang?METHOD of sample selection Ways used in this research are non probability sampling and sampling, where each consecutive samples that meet the criteria of insklusi included in the research so that the number of samples is filled.Data obtained through notes diman Medic using data from 34 people who were selected through age≤ 18 years of age who were treated in RSUP dr Kariadi SemarangRESULTS The results of this study found that factors the number of types of infection, the degree of previous sepsis, nutritional status and administration of antibiotics has a significant relationship with patient deaths at the installation sepsis PICU dr. Kariadi Semarang, while other factors such as length of treatment, medical treatment, and a history of labor does not significantly associated with patient deaths sepsis.CONCLUSION The results of this study found that factors the number of types of infection,, nutritional status and provision of antibiotics has a significant relationship with patient deaths at the installation sepsis PICU dr. Kariadi SemarangKEYWORDS AcinetobacterMDRO, Sepsi