Fibroblast growth factors and their receptors play a key role in cell proliferation, migration and differentiation.
Fibroblast growth factor receptor 2 (FGFR2) is involved in carcinogenesis and its altered expression has been
shown in several tumors, such as breast, thyroid and pancreatic cancer. The two isoforms of FGFR2 gene, FGFR2-
IIIb (also known as KGFR) and FGFR2-IIIc have been shown to exert differential roles in pancreatic cancer. FGFR2-
IIIc supports pancreatic cell proliferation, while overexpression of FGFR2-IIIb is correlated to major invasion and
metastasis formation. This review focuses on the role of FGFR2 signaling in pancreatic adenocarcinoma and the
potential use of FGFR2 tissutal expression as a predictive and/or prognostic marker. Moreover, it will discuss about
the potential use of strategies for FGFR2 signaling inhibition in the treatment of pancreatic cancer
