-activation inhibitory effects (firefly luciferase activity) of CPP–PNA conjugates in the HeLa cell reporter assay with delivery for 6 h in the presence of 100 µM chloroquine

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent -activation in cells"</p><p>Nucleic Acids Research 2005;33(21):6837-6849.</p><p>Published online 30 Nov 2005</p><p>PMCID:PMC1301599.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> () Stably-linked conjugates Tat–PNA (), TP–PNA (), TP10–PNA () and NLS–PNA–Tat (). () Disulfide-linked conjugates R–Pen-S-S–PNA (), mismatched conjugate (PNA sequence, CTCCGCAGCTCAGATC), scrambled conjugate (PNA sequence, ATCGCTCGCACCATGC), TP–S-S–PNA () and TP(int)–S-S–PNA (). Bars (left to right) in each case represent 2.5, 1.25, 0.625, 0.312 and 0 µM (light shaded bar) CPP–PNA concentrations. Control (black bar), absence of CPP–PNA and absence of chloroquine