Cancer Epidemiol Biomarkers Prev

Abstract

BackgroundLung cancer is one of the leading cancer sites diagnosed among Asian Americans, Pacific Islanders, and Native Hawaiians (AANHPI). To better understand the patterns of lung cancer incidence among AANHPIs, we examined the incidence trends of five histologic cell types of lung cancer across ten AANHPI populations in comparison with non-Hispanic Whites.MethodsLung cancer incidence data from 1990 through 2010 were obtained from 13 U.S. population-based cancer registries. Age-adjusted histologic cell-type\u2013specific incidence rates and 95% confidence intervals were calculated. Joinpoint regression models and annual percentage change (APC) statistics were used to characterize the magnitude and direction of trends.ResultsFrom 1990 through 2010, incidence rates of adenocarcinoma increased significantly for Filipino and Korean women with a 2.6% and 3.0% annual percentage increase, respectively. More recently, a significant rise in the incidence of adenocarcinoma was observed for Chinese men (1996\u20132010; APC = 1.3%). Squamous cell carcinoma (SCC) increased 2.4% per year among Japanese women. For SCC, small cell lung carcinoma, large cell and other specified carcinoma, and unspecified types, stable or decreasing trends were observed in most AANHPI groups and non-Hispanic Whites.ConclusionsAANHPIs demonstrate a range in the burden of lung cancer across histologies and specific populations.ImpactThese findings illustrate the importance of disaggregating AANHPIs into their specific populations. The rise in incidence of adenocarcinoma and SCC among certain AANHPIs demonstrates the need for research into non-tobacco associated risk factors for these populations and targeted efforts for tobacco prevention.HHSN261201000035C/PC,CA/None/NoneHHSN261201000140C/CA/NCI NIH HHS/United StatesU58 DP000807/DP/NCCDPHP CDC HHS/United States1U58 DP000807-01/DP/NCCDPHP CDC HHS/United StatesHHSN261201000035I/CA/NCI NIH HHS/United StatesP30 CA023100/CA/NCI NIH HHS/United StatesHHSN261201000034C/CA/NCI NIH HHS/United StatesN01 PC035137/PC/NCI NIH HHS/United States2017-12-21T00:00:00Z25368400PMC573846