Ruthenium-Catalyzed Enantioselective
Hydrogenation
of Aryl-Pyridyl Ketones
- Publication date
- Publisher
Abstract
Various substituted aryl-pyridyl ketones were hydrogenated
in the
presence of Ru-XylSunPhos-Daipen bifunctional catalytic system with
enantiomeric excesses up to 99.5%. Upon introduction of a readily
removable <i>ortho</i>-bromo atom to the phenyl ring, enantiomerically
enriched 4-chlorophenylpyridylmethanol was obtained by hydrogenation method
with 97.3% ee, which provided an important chiral intermediate for
some histamine H<sub>1</sub> antagonists
