DBU-Promoted Cyclization of <i>ortho</i>-(3-Hydroxy-1-alkynyl)benzamide: Synthesis of <i>trans</i>-3,4-Dihydroisoquinolin-1(2<i>H</i>)-ones and (<i>E</i>)-4-(1-Alkenyl)isoquinolin-1(2<i>H</i>)-ones

Abstract

DBU-promoted cyclization of <i>ortho</i>-(3-hydroxy-1-alkynyl)­benzamide is presented, providing an efficient method for the synthesis of <i>trans</i>-3,4-dihydroisoquinolin-1­(2<i>H</i>)-ones and (<i>E</i>)-4-(1-alkenyl)­isoquinolin-1­(2<i>H</i>)-ones under mild conditions