LRH-1 induces cell proliferation in 17β-estradiol and ICI 182,780 treated cells.

Abstract

<p>Cell proliferation was measured in pcDNA alone transfected, estrogen-deprived MCF-7 cells (control) or LRH-1 over-expressing (+LRH-1) MCF-7 cells treated with vehicle, 10 nM 17β-estradiol (E2) or 10 nM 17β-estradiol and 1 nM ICI 182,780, an ERα antagonist for 5 days. Data is presented as mean+SEM, n = 3 separate experiments, triplicate treatments per experiment, ***P&lt;0.001 compared to control transfected cells; a,b P&lt;0.001 compared to vehicle control.</p