Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: a rando...
Background & aims: Low levels of serum 25-hydroxy vitamin D (25(OH)D) are common in type 2 diabetic
patients and cause several complications particularly, in postmenopausal women due to their senile and
physiological conditions. This study aimed to assess the effects of vitamin D-fortified low fat yogurt on
glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal
women.
Methods: In a randomized, placebo-controlled, double-blind parallel-group clinical trial, 59 postmenopausal
women with type 2 diabetes received fortified yogurt (FY; 2000 IU vitamin D in 100 g/day)
or plain yogurt (PY) for 12 weeks. Glycemic markers, anthropometric indexes, inflammatory, and bone
turnover markers were assessed at baseline and after 12 weeks.
Results: After intervention, in FY group (vs PY group), were observed: significant increase in serum
25(OH)D and decrease of PTH (stable values in PY); significant improvement in serum fasting insulin,
HOMA-IR, HOMA-B, QUICKI, and no changes in serum fasting glucose and HbA1c (significant worsening
of all indexes in PY); significant improvement in WC, WHR, FM, and no change in weight and BMI (stable
values in PY); significant increase of omentin (stable in PY) and decrease of sNTX (significant increase in
PY). Final values of glycemic markers (except HbA1c), omentin, and bone turnover markers significantly
improved in FY group compared to PY group. Regarding final values of serum 25(OH)D in FY group,
subjects were classified in insufficient and sufficient categories. Glycemic status improved more significantly
in the insufficient rather than sufficient category; whereas the other parameters had more
amelioration in the sufficient category.
Conclusions: Daily consumption of 2000 IU vitamin D-fortified yogurt for 12 weeks improved glycemic
markers (except HbA1c), anthropometric indexes, inflammation, and bone turnover markers in postmenopausal
women with type 2 diabetes