RNAi suppression of dormancy upregulated genes accelerates tumor take and growth of ER+ luminal MCF-7 cells.

Abstract

<p>(A) Percent of tumor take at the indicated time points after injecting with 4 10⁶ MCF7 cells treated with the indicated siRNAs in the mouse mammary fat pad. (B) Tumor volume (mm³) at 12 days for tumors generated by MCF7 cells treated with the indicated siRNAs and injected in the mouse mammary fat pad. (C–D) Q-PCR analysis for the expression of BHLHE41 (C) and NR2F1 (D) mRNAs after 48 hrs of treatment with control or specific siRNAs targeting these mRNAs.</p