Corey–Itsuno Reduction
of Ketones: A Development
of Safe and Inexpensive Process for Synthesis of Some API Intermediates
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Abstract
A safe and inexpensive procedure for asymmetric reduction
of ketones
using in situ prepared <i>N</i>,<i>N</i>-diethylaniline
borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, <i>N</i>,<i>N</i>-diethylaniline hydrochloride and (<i>S</i>)-α,α-diphenylprolinol is described. This protocol
is demonstrated successfully to manufacture enantiopure dapoxetine
at the plant scale