Identification and conservation of a NRF-2/GABP binding site in the 5′-UTR of

Abstract

<p><b>Copyright information:</b></p><p>Taken from "The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors"</p><p>Nucleic Acids Research 2006;34(4):1205-1215.</p><p>Published online 25 Feb 2006</p><p>PMCID:PMC1383620.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> () Sequence alignment of homologs from several species showing a newly identified binding site for NRF-2. GenBank accession nos are as follows: (), (), (), (), (), (), (), () and (). The major transcription start site as identified in humans is shown and numbering is based on the human sequence (). Nucleotides conserved in all nine species are indicated with an asterisk. The underlined bases in the NRF-2 human sequence represent those changed for mutational analysis and the changes are shown in italics above the site. () Identification of the zebrafish promoter (GenBank accession no. ) and alignment with the human promoter (accession no. ). Boxes represent protein binding sites known to operate in humans that are conserved in zebrafish. Underlined sites represent potential positional differences between the two species for these factors. Conserved nucleotides are denoted with an asterisk