Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells-3

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells"</p><p>BMC Cancer 2006;6():60-60.</p><p>Published online 15 Mar 2006</p><p>PMCID:PMC1434759.</p><p>Copyright © 2006 Goffinet et al; licensee BioMed Central Ltd.</p> (0.5 μM, 8–10 Ci/mmol) incorporation into a mutant form of H-ras with a geranyl-geranylation CAXX box. The level of prenylation is expressed as a percentage of maximum incorporation of [H]-prenyl, as determined by allowing the uninhibited reaction to go to completion. : Western-blot analysis; PC-3 cells are treated by vehicle, ZOL 20 μM; ZOL 20 μM + FOH 10 μM; ZOL 20 μM + GGOH 10 μM