RNA cleavage with formation of 2′,3′-cyclic phosphate and 5′-hydroxyl termini

Abstract

<p><b>Copyright information:</b></p><p>Taken from " selection, characterization, and application of deoxyribozymes that cleave RNA"</p><p>Nucleic Acids Research 2005;33(19):6151-6163.</p><p>Published online 11 Nov 2005</p><p>PMCID:PMC1283523.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> This reaction can occur alone or with a catalyst such as a protein enzyme, ribozyme or deoxyribozyme. In most but not all cases, a divalent metal ion cofactor (M) is required to achieve an appreciable reaction rate