Dose-dependent inhibition of firefly luciferase translation by the mimic antisense oligomers targeted against the translational start site of FLuc mRNA

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Hydroxyproline-based DNA mimics provide an efficient gene silencing and "</p><p>Nucleic Acids Research 2006;34(8):2247-2257.</p><p>Published online 2 May 2006</p><p>PMCID:PMC1456331.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> () Sequences of HypNA-pPNA and pHypNA oligomers designed to target the FLuc mRNA; () Analysis of firefly luciferase translation inhibition by the oligomers. Firefly luciferase activity was calculated relative to the activity in the absence of any oligomer and normalized respect to luciferase production