Effect on sodium-dependent CAMG-uptake obtained in hSGLT1 or hSGLT2 treated with thioglycosides (10 µM each) or phlorizin (10 µM)

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"</p><p></p><p>International Journal of Medical Sciences 2007;4(3):131-139.</p><p>Published online 5 May 2007</p><p>PMCID:PMC1868657.</p><p>© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.</p> Results are expressed as percent of inhibition based on uptake in CHO cells expressing hSGLT1 or hSGLT2 not exposed to thioglycosides (control cells). Blue and red bars represent hSGLT1 and hSGLT2, respectively. Results are the mean of six different experiments. Error bars represents standard deviations. * < 0.01 shows significantly higher inhibition of sodium-dependent AMG uptake in treated cells as compared to control cells. Control uptake in CHO cells expressing hSGLT1 was 735 pmol/mg/h ± 22 pmol/mg/h and in CHO cells expressing hSGLT2 was 342 pmol/mg/h ± 15 pmol/mg/h