<p><b>Copyright information:</b></p><p>Taken from "MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models"</p><p>http://www.celldiv.com/content/2/1/22</p><p>Cell Division 2007;2():22-22.</p><p>Published online 19 Jul 2007</p><p>PMCID:PMC1941730.</p><p></p>carcinogen benzo[α]pyrene (B[α]P) in 100 μl acetone topically on their backs once per week for 20 weeks. Skin tumors started to appear after week 14, and increased in number during the course of B[α]P treatment. MIFmice developed nearly twice as many tumors per mouse as MIFcontrols. Based on histological evaluation by a blinded pathologist, this primarily reflected an increase of non-invasive tumors. By contrast, the number of invasive tumors was similar between the genotypes. Likewise, we found no significant difference with respect to tumor size or vascularization. * = statistically significant with p < 0.01 in a Student's t-test
