<p><b>Copyright information:</b></p><p>Taken from "Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly"</p><p>http://www.biomedcentral.com/1472-6807/7/45</p><p>BMC Structural Biology 2007;7():45-45.</p><p>Published online 2 Jul 2007</p><p>PMCID:PMC1936997.</p><p></p>ures were superimposed with TOPP [22]. () Active site of vvUDG. The active site of vvUDG with the glycerol (GOL) molecule at the center is shown in this stereo figure. The difference electron density for glycerol (F-Fomit map contoured at 3σ) is displayed (blue mesh). A second glycerol molecule away from the active site can also be seen. Active site residues are shown as stick models. () Active site of UDG (3EUG). Shown is a close-up view of the active site in UDG in the same orientation as the vvUDG in Fig. 3A. The bound glycerol (GOL) in the active site is shown in the center. Active site residues are shown as stick models. () Active site of vvUDG with modeled uracil. The active site of vvUDG was superimposed on the UDG active site containing uracil. The uracil molecule (URA) is modeled into the active site of vvUDG in the same position and orientation as seen in Fig. 3D for the structure (). The carbonyl oxygen atoms of uracil in this model superimpose with two hydroxyl groups in glycerol in the vvUDG structure. () Active site in UDG (). Shown is a close-up view of the active site in UDG with a bound uracil (URA) molecule in the same orientation as in Figs. 3A and 3B
