Effects of resveratrol on the expressions of Bcl-2 family members and IAPs

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential"</p><p>http://www.jmolecularsignaling.com/content/2/1/7</p><p>Journal of Molecular Signaling 2007;2():7-7.</p><p>Published online 24 Aug 2007</p><p>PMCID:PMC2018690.</p><p></p> (A and B), Effects of resveratrol on protein expression of Bcl-2 family members. Cells were treated with resveratrol (0–20 μM) for 24 or 48 h. The expressions of Noxa, Bim, Bak, Bax, Bid, PUMA, Bcl-2, and Bcl-Xwere examined by Western blot analysis. Actin antibody was used as a loading control. Bim= Bim extra large, Bim= Bim large, Bim= Bim short. (C), Effects of resveratrol on the expressions of IAPs. Cells were treated with resveratrol (0–20 μM) for 24 or 48 h. Crude proteins were subjected to SDS-PAGE and immunoblotted with antibody specific for XIAP, survivin, cIAP1 or cIAP2. β-actin antibody was used as a loading control

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