Representative immunohistochemical expression of p21 in male cystic and noncystic Han:SPRD rats (left), and male PKD and control humans (right)

Abstract

<p><b>Copyright information:</b></p><p>Taken from "p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels"</p><p>http://www.biomedcentral.com/1471-2369/8/12</p><p>BMC Nephrology 2007;8():12-12.</p><p>Published online 22 Aug 2007</p><p>PMCID:PMC2045080.</p><p></p> Upper panels show p21 localization from control sections, and the lower panels show cystic sections. Also shown are sections (NI) pre-incubated with non-immune serum that demonstrate antibody specificity. In sections from control male kidneys, p21 was widely distributed, whereas in sections from cystic male kidneys, p21 was only sparsely detected