High tidal volume ventilation caused a time-dependent increase on endothelial nitric oxide synthase activation

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment"</p><p>http://ccforum.com/content/11/4/R89</p><p>Critical Care 2007;11(4):R89-R89.</p><p>Published online 23 Aug 2007</p><p>PMCID:PMC2206484.</p><p></p> Phosphorylated endothelial nitric oxide synthase (eNOS) expressions (and , top panel), total eNOS protein expressions ((a) and (b), middle panel), and relative phosphorylation quantitation by arbitrary units ((a) and (b), bottom panel) were obtained from control nonventilated mice and from mice ventilated with tidal volume 30 ml/kg using room air or hyperoxia at indicated time periods (= 6/group). RA, mice with room air; O2, mice with hyperoxia. *< 0.05 versus control, nonventilated mice

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