Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome-0

Abstract

<p><b>Copyright information:</b></p><p>Taken from "Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome"</p><p>http://www.biomedcentral.com/1471-2172/8/28</p><p>BMC Immunology 2007;8():28-28.</p><p>Published online 13 Nov 2007</p><p>PMCID:PMC2211507.</p><p></p>omic DNA of Pt.1 and Pt.2. Circles represent females; squares, males; subjects carrying a CASP10 mutation are marked in black, those with a TNFRSF6 are marked with striped lines. Numbers indicate the cell survival upon Fas triggering by mAb in T cell lines generated form each subject; Fas function was defective in Pt.1 and borderline in the other subjects (normal values of cell survival: median 60%, 95percentile 82%