Cryosections from 30 day old op/op, wildtype and 12 month old APP-tg mice were examined using commercially available polyclonal antibodies for Aβ40 and Aβ42
<p><b>Copyright information:</b></p><p>Taken from "Osteopetrotic (op/op) mice have reduced microglia, no Aβ deposition, and no changes in dopaminergic neurons"</p><p>http://www.jneuroinflammation.com/content/4/1/31</p><p>Journal of Neuroinflammation 2007;4():31-31.</p><p>Published online 20 Dec 2007</p><p>PMCID:PMC2234402.</p><p></p> There was no Aβ40 immunoreactivity in op/op (A), wildtype (B) mice, whilst the APP-tg (C) mouse section showed some dense plaques. The Aβ42 specific antibody demonstrated a similar finding with op/op (D) and wildtype (E) mice having no plaques, whilst APP-tg (F) mice showed clear labeling of plaques. scale bar – 500 μm
