<p><b>Copyright information:</b></p><p>Taken from "Bunched, the homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth"</p><p>http://www.biomedcentral.com/1471-213X/8/10</p><p>BMC Developmental Biology 2008;8():10-10.</p><p>Published online 28 Jan 2008</p><p>PMCID:PMC2253523.</p><p></p>e () driver line. (A) EP-mediated expression of does not produce a wing bending phenotype. (B) Overexpression of in the dorsal wing compartment leads to wing bending (was co-expressed as a control). The bent-down wing phenotype is enhanced when the EP-insertion (C) or a transgene (D) is used to co-overexpress . Expression of from the EP consistently results in stronger phenotypes than from the transgene. (E) Co-overexpression of leads to a complete suppression of the bent-down wing phenotype. (F) Expression of suppresses the bent-down wing phenotype, and the suppression is even stronger when a copy of is removed (G), indicative of a dominant negative effect of on . Consistently, co-expression of interferes with the suppressing effect of (H)
