<p><b>Copyright information:</b></p><p>Taken from "Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration"</p><p></p><p>Molecular Vision 2008;14():150-160.</p><p>Published online 29 Jan 2008</p><p>PMCID:PMC2254958.</p><p></p> Following periocular administration of 400 µg dose of 20 nm particles to live rats, the nanoparticles can be found in the organs of the reticulo-endothelial system (liver and spleen). The various tissues including the eye, the periocular tissue, the liver and the spleen were removed and sectioned 6 h after administration. The figure shows the fluorescence images of sections of the: eye (Panels and ); periocular tissue (Panels and ); liver (Panels and ); and spleen (Panels and ). The left panels (, , , and ) are fluorescence images from control rats that were not dosed with the nanoparticles whereas the right panels (, , , and ) are images from the rats that were dosed with the nanoparticles. Nanoaprticles can be seen in the periocular tissue, spleen and to some extent in the liver of the dosed animals
