Aaptamine Derivatives from the Indonesian Sponge <i>Aaptos suberitoides</i>

Abstract

Four new aaptamine derivatives (<b>1</b>–<b>4</b><b></b>) along with aaptamine (<b>5</b>) and three related compounds (<b>6</b>–<b>8</b>) were isolated from the ethanol extract of the sponge <i>Aaptos suberitoides</i> collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds <b>3</b>, <b>5</b>, and <b>6</b> showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC₅₀ values ranging from 0.9 to 8.3 μM