Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis-10
Ocytes were distributed predominantly within the internal granule cell layer () and the white matter tracts in the cerebellum (), whereas Rip-positive processes of the mutant cerebellum were distorted and irregularly arranged, and sparsely distributed within the (). , Higher magnifications of the molecular layer (), Purkinje cell layer () and shown in A and B, respectively. The cerebellar oligodendrocytes in rats exhibited irregularly aligned short processes. , The number, density and distribution pattern of neurofilament-positive axons in cerebellar folia () were indistinguishable from those in the cerebellar folia (). Scale bars: 50 μm (A, B, C, D); 25 μm (A', B'). , internal granule cell layer; , molecular layer; , Purkinje cell layer.<p><b>Copyright information:</b></p><p>Taken from "Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis"</p><p>http://www.biomedcentral.com/1471-2202/9/35</p><p>BMC Neuroscience 2008;9():35-35.</p><p>Published online 5 Apr 2008</p><p>PMCID:PMC2323389.</p><p></p
