Ct the optimal network structure based on the LOF and GOF microarray datasets, evolutionarily conserved TFBS data, prior literature-based knowledge, and spatial and time-specific expression patterns. To highlight the key regulators, the nodes representing genes predicted to be the parent of at least nine other genes are largest in size (Sox9, Mef2a, Elavl4 and Pou6f1), whereas those that are predicted to regulate at least five other genes are medium in size (Ngn2, Centg3, Tef, Tcf4, Wnt7b, Pou2f1, Yy1, Dll1, E2f1, Arx, and Creb). See Additional file for matrix of connectivity and Methods for a more detailed description of algorithm.<p><b>Copyright information:</b></p><p>Taken from "Characterization of the proneural gene regulatory network during mouse telencephalon development"</p><p>http://www.biomedcentral.com/1741-7007/6/15</p><p>BMC Biology 2008;6():15-15.</p><p>Published online 31 Mar 2008</p><p>PMCID:PMC2330019.</p><p></p
