Concentration-effect relationships of ibandronate on cancer cell proliferation in hypocalcaemic or hypercalcaemic conditions

Abstract

MDA-MB-231 and MCF-7 cells were exposed for 72 hours to increasing ibandronate concentrations (1 to 1,000 μmol/l) in culture medium containing 0.6 mmol/l calcium (filled squares) or 1.6 mmol/l calcium (open squares). Cell culture densities were evaluated by crystal violet staining assay. Data are presented as percentages (mean ± standard deviation) of control values, which refer to cultures with 0.6 mmol/l calcium and without ibandronate. Mean of results pooled from three experiments (= 18). *< 0.01 versus 0.6 mmol/l calcium, analysis of variance, Tukey test.<p><b>Copyright information:</b></p><p>Taken from "Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells"</p><p>http://breast-cancer-research.com/content/10/1/R4</p><p>Breast Cancer Research : BCR 2008;10(1):R4-R4.</p><p>Published online 11 Jan 2008</p><p>PMCID:PMC2374955.</p><p></p

    Similar works

    Full text

    thumbnail-image

    Available Versions