Effects of CaR agonist and antagonist on growth inhibition caused by ibandronate in cancer cells

Abstract

MDA-MB-231 and MCF-7 cells were incubated for 72 hours with 30 μmol/l ibandronate (Iban) and/or calcium-sensing receptor (CaR) agonist in culture medium containing 0.6 mmol/l calcium, or with 30 μmol/l ibandronate and/or CaR antagonist in culture medium containing 1.6 mmol/l calcium. Cell culture densities were evaluated by crystal violet staining assay. Data are presented as percentages (mean ± standard deviation) of control values, which refer to culture with 0.6 mmol/l calcium and without drugs. Mean of results pooled from two experiments (= 12). *< 0.01 versus control, analysis of variance, Dunnett test.<p><b>Copyright information:</b></p><p>Taken from "Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells"</p><p>http://breast-cancer-research.com/content/10/1/R4</p><p>Breast Cancer Research : BCR 2008;10(1):R4-R4.</p><p>Published online 11 Jan 2008</p><p>PMCID:PMC2374955.</p><p></p

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