The influence of nicotine on granulocytic differentiation – Inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release-6
HL-60 cells stimulated with LPS (1.0 μg ml) plus nicotine (10M, Lane 2); compared to LPS alone (Lane 1). Nicotine-induced augmentation of LPS-induced MMP-9 activity is abrogated by pre-incubation of DMSO-differentiated HL-60 cells with an α7-type nAChR inhibitor (α-bungarotoxin, 200 ng ml, Lane 3). Relative fold increases (mean, s.d.) in MMP-9 gelatinolytic activity were quantified by densitometry (= 5, * < 0.05, < 0.01). Error bars represent standard deviations of the mean.<p><b>Copyright information:</b></p><p>Taken from "The influence of nicotine on granulocytic differentiation – Inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release"</p><p>http://www.biomedcentral.com/1471-2121/9/19</p><p>BMC Cell Biology 2008;9():19-19.</p><p>Published online 15 Apr 2008</p><p>PMCID:PMC2375863.</p><p></p
