Ombinations of growth factors and lactogenic hormones. Lines 31E +30F co-cultures containing either pBabeVector or pBabeSFRP-4-infected Line 31E cells were compared. Most notable is that Wnt-3a is capable of completely suppressing the differentiation to β-casein expression stimulated by dexamethazone-insulin-prolactin (DIP). However, co-cultures containing Line 31E cells infected with SFRP-4 show definite β-casein induction in spite of Wnt-3a treatment. Ribosomal RNA was stained with acridine orange as a loading control.<p><b>Copyright information:</b></p><p>Taken from "SFRP-4 abrogates Wnt-3a-induced β-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of mammary differentiation"</p><p>http://www.jmolecularsignaling.com/content/3/1/10</p><p>Journal of Molecular Signaling 2008;3():10-10.</p><p>Published online 2 May 2008</p><p>PMCID:PMC2412851.</p><p></p
