The frozen sections of cerebral cortices from TLR4m (A and B) and TLR4w (C and D) AD mice were stained with anti-GFAP antibody. Scale bars are 50 μm in A and C, and 10 μm in B and D. The middle images (B and D) are a high magnification of the areas indicated by the squares in the top images (A and C). GFAP immunoreactive area percentages of TLR4m and TLR4w AD mice were shown as a bar graph (means ± SE, **P < 0.001) (E). Approximately 15 fields of the cerebral cortex (0.5 to 1 mmeach, using a 10× objective and 1× eyepiece lens) from 4 – 5 coronal brain sections, each separated by more than 240 μm interval, from each mouse were analyzed. TLR4m and TLR4w represent TLR4m and TLR4w AD mice, respectively.<p><b>Copyright information:</b></p><p>Taken from "Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease"</p><p>http://www.jneuroinflammation.com/content/5/1/23</p><p>Journal of Neuroinflammation 2008;5():23-23.</p><p>Published online 29 May 2008</p><p>PMCID:PMC2430555.</p><p></p
