SFRP-4 abrogates Wnt-3a-induced β-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of mammary differentiation-8

Abstract

of Dvl-3. Following treatment with Wnt-3a for the indicated times, cells were lysed with Triton X-100 Lysis Buffer and cell extracts were subjected to Western blot analysis. Hyperphosphorylation of Dvl-3 is evident by a consistent relative increase in the intensity of the upper band of the doublet. Alkaline phosphatase treatment caused the loss of the upper band (data not shown).<p><b>Copyright information:</b></p><p>Taken from "SFRP-4 abrogates Wnt-3a-induced β-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of mammary differentiation"</p><p>http://www.jmolecularsignaling.com/content/3/1/10</p><p>Journal of Molecular Signaling 2008;3():10-10.</p><p>Published online 2 May 2008</p><p>PMCID:PMC2412851.</p><p></p